Wolves' season continued to spiral after Fulham condemned them to another damaging defeat to keep them winless and bottom of the Premier League.
Ryan Sessegnon, Harry Wilson and Yerson Mosquera's own goal ended the Cottagers' four-game losing run, while Wolves' Emmanuel Agbadou was sent off in the first half.
The visitors did little to prove their wretched start would end in west London and have now lost eight of their 10 league games.
There is still belief at Molineux that boss Vitor Pereira can save the season - and a reluctance to sack him - but Wolves are now eight points from safety and being cut adrift.
Fulham piled on the misery when Sessegnon struck early, seizing on a mistake from Santi Bueno, and it got worse when Agbadou was dismissed nine minutes before half-time - after his clumsy foul on Josh King denied a goalscoring opportunity.
The visitors never recovered and Sam Johnstone denied Kenny Tete and Wilson but the Wales winger secured victory, which lifted the Cottagers to 14th, with a fine low finish from 20 yards.
There was still time for Mosquera to turn the ball into his own net with 15 minutes left to add to Wolves' woes, before Samuel Chukwueze hit the bar late on for Marco Silva's side.
