Wales suffered a ninth successive international defeat as Australia wrapped up the series 2-0 with victory in an eight-try thriller in Melbourne.
Two tries from Filipo Daugunu, further scores from Jake Gordon and Allan Alaalatoa and 13 points from Noah Lolesio's boot helped Australia achieve a successful start to Joe Schmidt's era following the 25-16 win in Sydney last weekend.
Wales responded with two tries from inspirational captain Dewi Lake, while wings Liam Williams and Rio Dyer also crossed.
Warren Gatland's side rallied from a sluggish start as they slipped to a 17-0 deficit inside 25 minutes, but left themselves with too much work to do.
Lake has been the Wales success story of this tour with his tries coming from rolling mauls, which have proved the tourists' most potent attacking threat.
Wales produced some encouraging moments but were punished for indiscipline, making too many mistakes and not taking opportunities they created.
