Daniel Podence's scuffed finish in first-half stoppage time was enough for Wolves to see off Southampton and claim their first win in 13 Premier League matches.
The hosts had scored just twice in their opening five league games this season, which helped to explain why 6ft 7in striker Sasa Kalajdzic was handed his debut just days after arriving from Stuttgart.
But the Austria international endured a dispiriting afternoon, meaning it was instead left to Podence to secure the points for Bruno Lage's side, which he did when he just about managed to turn Matheus Nunes' cross past the sprawling Gavin Bazunu.
Southampton - who came into the game on the back of an impressive home win against Chelsea - were unable to match that midweek performance, and ended the game with just one shot on target at Molineux.
