Real are one of the 12 European clubs who have signed up to the breakaway league and intend to establish a new midweek competition.
Perez said the move had been made because young people are "no longer interested in football" because of "a lot of poor quality games".
"Whenever there is change, there are always people who oppose it," he said.
The English 'big six' of Arsenal, Chelsea, Liverpool, Manchester City, Manchester United and Tottenham have agreed to join the new league.
The move has been criticised by football authorities and government ministers in the UK and widely condemned across Europe by Uefa and leagues associations.
Prime Minister Boris Johnson will hold a meeting with football's governing bodies on Tuesday to discuss the move, while the 14 Premier League clubs not included in the plans are also scheduled to meet.
Perez said that the top teams were losing money and that big-name matches would help increase their revenue.
"We are doing this to save football at this critical moment," Perez told Spanish TV show El Chiringuito de Jugones.
"If we continue with the Champions League there is less and less interest and then it's over.
"The new format which starts in 2024 is absurd. In 2024, we are all dead."
Plans for a revamped 36-team Champions League, starting in 2024, were confirmed by Uefa on Monday.
He added: "In the '50s, it was a similar situation. Uefa and Fifa went against the new European Cup, but that competition changed football."
Perez said the move had been accelerated by the coronavirus pandemic, which has led to matches being played behind closed doors.
He claimed 40% of young people are not interested in football and Real have lost 400m euros (£344m) because of the impact of the pandemic.
"When you don't have any income other than from television, you have to find a solution to make more attractive matches that fans all over the world can watch with all of the big clubs," said Perez.
"Young people are no longer interested in football. They have other platforms on which to distract themselves.
"We could get back some of the money we lost because of the pandemic. We have to raise more money organising more competitive games."
However, critics say the move is being driven purely by money, would destroy domestic leagues and is against the integrity of the sport.
Former England captain Alan Shearer said he hoped the English clubs would consider the reaction of their fans, which has been overwhelmingly negative.
"Clubs talk about being a family and how fans are the soul of the club," Shearer told BBC Breakfast.
"Well, let's see what they really think about the fans, because the fans have now spoken.
"It is clearly obvious that they don't want this, so let's see what their fans mean to the football clubs."
Another three teams will be added to the league as guaranteed members, with five more qualifying each year.
Perez said the group want to start the new league by August, should they reach an agreement with Uefa, otherwise it could be delayed by a year.
Uefa president Aleksander Ceferin called the league a "disgraceful, self-serving" plan and a "spit in the face of football lovers".
Ceferin also said that players involved with the ESL could be banned from all Uefa competitions, which Perez denied.
"It will not happen, the law protects us," Perez added.
"We will not get into legal issues. It is impossible. The players should remain calm because the threats won't happen. "This is not a league for the rich, it's a league to save football."
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